Comparing methods for plasma HDV RNA quantification in bulevirtide-treated and untreated patients with HDV
Management and diagnosis of chronic hepatitis delta (CHD) require standardized tests for HDV RNA quantification. Quantification of HDV RNA is significantly influenced by the quantification method, with EurobioPlex detecting approximatively 1 log and AltoStar 0.5 log IU/ml more than Robogene 2.0, respectively. The HDV RNA undetectability rates during BLV monotherapy significantly differed among assays. These findings are of clinical relevance as patients who achieve negative viremia during BLV monotherapy might be entitled to stop therapy successfully.
Authors
- Sara Monico (ORCID: https://orcid.org/0000-0001-5359-850X)
- R. Soffredini
- Sara Uceda Renteria (ORCID: https://orcid.org/0000-0002-2027-8478)
- Maria Paola Anolli (ORCID: https://orcid.org/0000-0001-6901-5575)
- Marta Borghi
- Riccardo Perbellini (ORCID: https://orcid.org/0000-0002-4412-1256)
- Dana Sambarino
- Elisabetta Degasperi (ORCID: https://orcid.org/0000-0002-9899-4669)
- F. Facchetti (ORCID: https://orcid.org/0000-0001-5252-4744)
- Annapaola Callegaro (ORCID: https://orcid.org/0000-0002-6793-4989)
- Pietro Lampertico (ORCID: https://orcid.org/0000-0002-1026-7476)
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101299
- Citations
- 4
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Università degli Studi di Milano