Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation
This study highlighted the efficacy of ailanthone against HCC and elucidated its underlying molecular mechanisms, suggesting the promising therapeutic potential of ailanthone for HCC.
Authors
- Ming Zhao (ORCID: https://orcid.org/0000-0002-7539-3887)
- Guan Liu (ORCID: https://orcid.org/0000-0001-6924-5709)
- Ying Gao (ORCID: https://orcid.org/0000-0002-3245-7457)
- Qin Yan (ORCID: https://orcid.org/0000-0002-3974-0298)
- Jingyue Yao
- Le Yang
- Chang Su (ORCID: https://orcid.org/0000-0003-4857-2414)
- Dan Wu (ORCID: https://orcid.org/0000-0003-2873-1182)
- Qingqing Liu (ORCID: https://orcid.org/0009-0000-9751-518X)
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-11
- DOI
- https://doi.org/10.3389/fphar.2024.1509482
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China