Characterizing the Origins of Primary Aldosteronism
The pathophysiologic continuum of PA, characterized by renin-independent and adrenocorticotropic hormone-mediated aldosterone production, and enhanced aldosterone synthase and mineralocorticoid receptor activity, is evident in normotensive people. These findings provide mechanistic explanations to implicate PA in the pathogenesis of a substantial proportion of hypertension.
Authors
- David G. Stouffer (ORCID: https://orcid.org/0009-0008-9453-8819)
- Brooke Honzel (ORCID: https://orcid.org/0009-0005-2824-903X)
- Richard Joseph Auchus (ORCID: https://orcid.org/0000-0001-6815-6181)
- Michael D. Cherney (ORCID: https://orcid.org/0000-0001-8422-5319)
- Anand Vaidya (ORCID: https://orcid.org/0000-0002-0314-9252)
- Jenifer M. Brown (ORCID: https://orcid.org/0000-0002-6647-639X)
- Julia Milks
- Laura C Tsai (ORCID: https://orcid.org/0009-0008-5344-2589)
- Andrew J Newman (ORCID: https://orcid.org/0000-0002-8326-1964)
- Yvonne Neibuhr
Institutions
- Brigham and Women's Hospital (US)
- Veterans Health Administration (US)
- Michigan Medicine (US)
- Cardiovascular Research Center (BR)
- Hypertension Institute (US)
Publication Details
- Journal
- Hypertension
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1161/hypertensionaha.124.24153
- Citations
- 17
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 6.08