C–H Functionalization of Quinoxalines

Abstract As a powerful tool in modern organic synthesis, C–H functionalization offers an elegant shortcut to molecular complexity, enabling direct bond transformations without any pre-functionalization. In this connection, the C–H functionalization of quinoxalines offers a direct and efficient approach to modify the quinoxaline scaffold, a key structural motif in biologically active compounds and materials. This personal account describes the methodologies developed by our group for the C–H activation and functionalization of quinoxaline compounds. 1 Introduction 2 Difluoroalkylamidation 3 ortho C–H Alkylation 4 ortho C–H Amination 5 Conclusion