Direct Accessing γ-Pyridyl Tertiary Alcohols through Metal-Free Three-Component Reactions

Abstract Herein, we introduce a novel method for synthesizing γ-pyridyl alcohols from readily accessible alcohols. This process is a metal-free, three-component reaction that elegantly combines alcohols, vinylarenes, and 4-cyanopyridine. The versatility of this reaction is showcased through its successful application in the late-stage functionalization of pharmaceutical molecules.