Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum
Our study suggests a modest association between current gabapentinoid use and fractures in patients with IA, after accounting for measured and time-invariant unmeasured confounding. Whilst other unmeasured confounding remains possible, given the absence of evidence for gabapentinoid efficacy in patients with IA who are particularly vulnerable to fractures, this highlights a need for efforts to deliver safer gabapentinoid prescribing in this population.
Authors
- Ian C. Scott (ORCID: https://orcid.org/0000-0002-1268-9808)
- James Bailey (ORCID: https://orcid.org/0000-0002-2566-3527)
- Christian Mallen (ORCID: https://orcid.org/0000-0002-2677-1028)
- Helen Twohig (ORCID: https://orcid.org/0000-0001-8781-1268)
- Samantha Hider (ORCID: https://orcid.org/0000-0002-9958-3909)
- Norwati Daud (ORCID: https://orcid.org/0000-0003-4998-3493)
- Kelvin P. Jordan (ORCID: https://orcid.org/0000-0003-4748-5335)
- Sara Müller (ORCID: https://orcid.org/0000-0001-6645-5751)
Institutions
- Midlands Partnership NHS Foundation Trust (GB)
- Arthritis UK (GB)
- Keele University (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1186/s12916-024-03774-5
- Citations
- 5
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.35
Funders
- National Institute for Health and Care Research
- Versus Arthritis
- Arts and Humanities Research Council
- Medical Research Council