Dosimetric Investigation of Acetaminophen Drug Raw Materials by Electron Paramgangnetic Resonance Spectroscopy

In this study, powdered crystals of paracetamol, a drug active ingredient known for its use in alleviating postoperative pain and as an adjuvant in chemotherapy for cancer patients, were exposed to gamma radiation. The paramagnetic defects induced by the radiation were thoroughly investigated using Electron Paramagnetic Resonance (EPR) spectroscopy. The suitability of the drug sample for use as a dosimetric material, radical extinction data, saturation information occurring at microwave power values and parameters related to dose-response data were investigated at room temperature. No EPR signal was observed in the sample which was not exposed to gamma radiation. Spectroscopic properties generated as a result of radiation were determined via spectrum simulation.