Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer
Among individuals with early-onset colorectal cancer, germline VUS reclassification as well as rates of VUSs in cancer susceptibility genes differed by self-identified race/ethnicity. These findings point to the importance of VUS reclassification as this may alter clinical management and to distinct germline variant spectra among diverse patients with early-onset colorectal cancer.
Authors
- Carolyn Horton (ORCID: https://orcid.org/0000-0001-5186-6208)
- Sean V. Tavtigian (ORCID: https://orcid.org/0000-0002-7543-8221)
- Andreana N. Holowatyj (ORCID: https://orcid.org/0000-0001-8001-8793)
- Rachel A. Francis (ORCID: https://orcid.org/0000-0001-5512-7226)
Institutions
- Vanderbilt University (US)
- University of Utah (US)
- Utah Department of Health (US)
- Ambry Genetics (United States) (US)
- Vanderbilt-Ingram Cancer Center
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0368
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Pfizer
- Bayer
- National Institutes of Health
- National Institute of Child Health and Human Development