[<i>Mycobacterium tuberculosis</i> infection complicated by talaromycosis in a patient with positive anti-interferon-γ autoantibodies: a case report].

High-titer antibodies to interferon-gamma (IFN-γ) are strongly correlated with infections caused by intracellular pathogens, particularly non-tuberculous mycobacteria and <i>Talaromyces marneffei</i> (TM). However, cases of concurrent infections with TM and <i>Mycobacterium tuberculosis</i> (MTB) in non-immunosuppressed patients are extremely rare. We presented a clinical case of a patient with anti-IFN-γ autoantibodies who developed an MTB infection complicated by <i>Talaromyces marneffei</i>, which subsequently led to secondary hemophagocytic syndrome. This report aimed to raise clinicians' awareness of this rare association to minimize the risk of misdiagnosis and overdiagnosis.