Genomic perspective on the bacillus causing paratyphoid B fever
Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.
Authors
- Jane Hawkey (ORCID: https://orcid.org/0000-0001-9661-5293)
- Anna Zhukova (ORCID: https://orcid.org/0000-0003-2200-7935)
- Dominique Clermont (ORCID: https://orcid.org/0000-0002-6018-2462)
- Yukihiro Akeda (ORCID: https://orcid.org/0000-0002-5325-4173)
- Sandra Simon (ORCID: https://orcid.org/0000-0002-7928-3503)
- Véronique Guibert
- Brent Jenkins (ORCID: https://orcid.org/0000-0003-2907-660X)
- Lise Frézal (ORCID: https://orcid.org/0000-0002-6518-0423)
- Carolina Silva Nodari (ORCID: https://orcid.org/0000-0002-2361-5732)
- Marie Anne Chattaway (ORCID: https://orcid.org/0000-0002-5288-9089)
- Hidemasa Izumiya (ORCID: https://orcid.org/0000-0002-9797-7402)
- Masatomo Morita (ORCID: https://orcid.org/0000-0002-2850-0053)
- Xuebin Xu (ORCID: https://orcid.org/0000-0002-9554-3782)
- Elisabeth Njamkepo (ORCID: https://orcid.org/0000-0001-6791-6003)
- François‐Xavier Weill (ORCID: https://orcid.org/0000-0001-9941-5799)
- Martin Cormican (ORCID: https://orcid.org/0000-0002-8023-1882)
- Martin Hunt (ORCID: https://orcid.org/0000-0002-8060-4335)
- Z. N. Matveeva (ORCID: https://orcid.org/0000-0002-7173-2255)
- Niall De Lappe
- Л. А. Кафтырева (ORCID: https://orcid.org/0000-0003-0989-1404)
- Patricia I. Fields (ORCID: https://orcid.org/0000-0003-1199-2650)
- María Pardos de la Gándara (ORCID: https://orcid.org/0000-0002-3273-6392)
- Magali Ravel
- Sylvie Issenhuth-Jeanjean
- Derek Brown (ORCID: https://orcid.org/0000-0003-3742-8257)
- Min Yue (ORCID: https://orcid.org/0000-0002-6787-0794)
- Zamin Iqbal (ORCID: https://orcid.org/0000-0001-8466-7547)
- М. А. Макарова (ORCID: https://orcid.org/0000-0003-3600-2377)
- Estelle Serre
- Yanan Wang (ORCID: https://orcid.org/0000-0002-7461-2195)
- Laëtitia Fabre (ORCID: https://orcid.org/0009-0003-9048-663X)
- Junko Isobe
- Baoli Zhu (ORCID: https://orcid.org/0000-0001-5326-9503)
- Alicia Tran Dien
Institutions
- Centers for Disease Control and Prevention (US)
- European Bioinformatics Institute (GB)
- Institut Pasteur (FR)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Chinese Academy of Sciences (CN)
- Université Paris Cité (FR)
- Robert Koch Institute (DE)
- Institut Gustave Roussy (FR)
- University Hospital Galway (IE)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- National Institute of Infectious Diseases (JP)
- Toyama Institute of Health (JP)
- Saint Petersburg Pasteur Institute (RU)
- Institute of Microbiology (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
- University of Chinese Academy of Sciences (CN)
- Henan Agricultural University (CN)
- University of Bath (GB)
- Monash University (AU)
- Zhejiang University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1038/s41467-024-54418-4
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- National Institute for Health Research Health Protection Research Unit
- Fondation Le Roch-Les Mousquetaires
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Warwick
- University of Oxford
- Agence Nationale de la Recherche
- Centers for Disease Control and Prevention
- NIHR Oxford Biomedical Research Centre