Comparision of Perioperative Fluoropyrimidine, Docetaxel And Oxaliplatin Regimen with Adjuvant Fluoropyrimidine and Oxaliplatine Regimen In Operable Gastric Cancer Patients

Aim: As no study has compared perioperative 5-Fluorouracil (5-FU), oxaliplatin, and docetaxel (FLOT) chemotherapy regimens with postoperative adjuvant oral capecitabine and oxaliplatin/5-FU and oxaliplatin (CAPEOX/FOLFOX) chemotherapy regimens, the goal of this study was to compare them in terms of median and overall survival of operable gastric cancers. Methods: This single-center, retrospective study recruited 59 subjects (17 females and 42 males) with at least T2 or more invasive gastric cancers with or without positive lymph node(s). All the patients underwent total or subtotal ((sub) total) gastric resection with D2 lymph node dissection. The Statistical Package for the Social Sciences (IBM SPSS) 26.0 program was used to statistically analyze the research findings. Results: The peri-operative FLOT treatment group with 30 patients displayed significantly more advanced clinical nodal (cN) stage (p