Drug-induced megacolon in schizophrenia: a pharmacovigilance study of antipsychotic medications from the Japanese Adverse Drug Event database: a disproportionality analysis

Zotepine, sulpiride, and quetiapine are associated with antipsychotic-induced megacolon in schizophrenia patients, and it is suggested that there is a gender difference. This study provides novel evidence for evaluating adverse drug events related to schizophrenia pharmacotherapy, contributing to improved quality of life for these patients.

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Publication Details

Journal
Expert Opinion on Drug Safety
Published
2024-12-10
DOI
https://doi.org/10.1080/14740338.2024.2441288
Primary Topic
Gastrointestinal motility and disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Drug-induced megacolon in schizophrenia: a pharmacovigilance study of antipsychotic medications from the Japanese Adverse Drug Event database: a disproportionality analysis

Junji Saruwatari, Yuki Kondo, Norio Sugawara, Keita Tokumitsu et al.
Expert Opinion on Drug Safety
Gastrointestinal motility and disorders
article

Drug-induced megacolon in schizophrenia: a pharmacovigilance study of antipsychotic medications from the Japanese Adverse Drug Event database: a disproportionality analysis

Junji Saruwatari, Yuki Kondo, Norio Sugawara, Keita Tokumitsu, Norio Yasui‐Furukori
article en

Abstract

Zotepine, sulpiride, and quetiapine are associated with antipsychotic-induced megacolon in schizophrenia patients, and it is suggested that there is a gender difference. This study provides novel evidence for evaluating adverse drug events related to schizophrenia pharmacotherapy, contributing to improved quality of life for these patients.

Expert Opinion on Drug Safety
Towada City Hospital (JP), Dokkyo Medical University (JP), Kumamoto University (JP)
Good health and well-being
Openalex Percentile: Top 59%
Gastrointestinal motility and disorders
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