Research on the Extraction Conditions of Naringin, Antioxidant, Antibacterial Properties From Duong La Cam Pomelo Peel, Vietnam

Objective Naringin was known to be a flavonoid compound with many biological activities and was present in pomelo peel. Duong La Cam pomelo was a speciality grapefruit in Tan Trieu commune, Vinh Cuu district, Dong Nai province. This study evaluated Duong La Cam pomelo extract's naringin content and antioxidant and antibacterial activities. Method Duong La Cam pomelo extract was extracted by ultrasonic method. Naringin content was determined based on the naringin standard curve. Biological activities were evaluated by DPPH, ABTS, Agar disk-diffusion method and The minimum inhibitory concentration (MIC). Results The research results of enriching the Naringin component in the Duong La Cam Pomelo extract were recorded with a content of 114 mg/gDW. Duong La Cam Pomelo extract was extracted by ultrasonic method with solvent and raw material ratio 1 g/10 mL, time 60 min, temperature 70 °C and using 80% Ethanol solvent. The results showed antioxidant capacity with IC 50 values of 0.127 mg/mL (ABTS); 14 511 mg/mL (DPPH). Besides, the antibacterial ability of the sample was also recorded at the minimum inhibitory concentration of Escherichia coli of 2.5 mg/mL and Staphylococcus aureus of 5 mg/mL. Conclusions The study showed that the ultrasonic extraction method saves time but still ensures high naringin content and good activity in extraction. It can be seen that naringin extract from Duong La Cam grapefruit has great potential for application in the medical field.