Differential Expression Analyses on Human Aortic Tissue Reveal Novel Genes and Pathways Associated With Abdominal Aortic Aneurysm Onset and Progression
This study identifies new genes and splicing patterns associated with AAAs and validates previous relevant pathways on AAAs. These findings contribute to the understanding of the complex mechanisms underlying AAAs and may provide potential targets to limit AAA progression and mortality risk.
Authors
- Olga Peypoch (ORCID: https://orcid.org/0000-0002-9795-5553)
- Lluís Nieto (ORCID: https://orcid.org/0009-0002-5744-9266)
- Laura Calsina Juscafresa (ORCID: https://orcid.org/0000-0002-8140-7800)
- Andrew Brown (ORCID: https://orcid.org/0000-0002-8087-3033)
- Maria Sabater‐Lleal (ORCID: https://orcid.org/0000-0002-0128-379X)
- Ana Viñuela (ORCID: https://orcid.org/0000-0003-3771-8537)
- Gerard Temprano‐Sagrera (ORCID: https://orcid.org/0000-0001-6136-8915)
- Mercedes Camacho (ORCID: https://orcid.org/0000-0001-5970-3294)
- Jaume Dilmé (ORCID: https://orcid.org/0000-0003-0127-0064)
- José Román Escudero (ORCID: https://orcid.org/0000-0003-3929-6403)
- Beatriz Beseler Soto (ORCID: https://orcid.org/0000-0002-5965-1292)
- David Davtian
- Mireia de la Rosa Estadella
Institutions
- Universitat Pompeu Fabra (ES)
- University of Dundee (GB)
- Hospital de Sant Pau (ES)
- Ninewells Hospital (GB)
- Karolinska Institutet (SE)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Del Mar (ES)
- Genomics (United Kingdom) (GB)
- Institut de Recerca Sant Pau (ES)
- Newcastle University (GB)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1161/jaha.124.036082
- Citations
- 4
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Tenovus
- Ministerio de Ciencia e Innovación
- Servier
- Instituto de Salud Carlos III
- European Regional Development Fund