Oxyphosphorodithiolation of Vinyl Azides with P<sub>4</sub>S<sub>10</sub> and Alcohols Leading to β-Keto Phosphorodithioates
A simple strategy for the synthesis of β-keto phosphorodithioates has been developed through the direct oxyphosphorodithiolation of vinyl azides with P<sub>4</sub>S<sub>10</sub> and alcohols in the presence of water. The reaction is conducted at room temperature to provide a number of β-keto phosphorodithioates in moderate to good yields. This methodology has the advantages of simple operation, mild condition, broad substrate scope, and favorable group compatibility.
Authors
- Huilan Yue (ORCID: https://orcid.org/0000-0003-4457-3233)
- Wenhui Gao (ORCID: https://orcid.org/0000-0001-9501-885X)
- Dong Yi (ORCID: https://orcid.org/0000-0002-8281-7860)
- Wei Wei (ORCID: https://orcid.org/0000-0002-0015-7636)
- Jian Sun (ORCID: https://orcid.org/0000-0001-8964-6227)
- Chao Ma (ORCID: https://orcid.org/0000-0003-1444-4668)
- Jian Huang
- Yufen Lv (ORCID: https://orcid.org/0009-0003-9634-304X)
Institutions
- Qufu Normal University (CN)
- Southwest Medical University (CN)
- Qinghai Tibetan Hospital (CN)
- Northwest Institute of Plateau Biology
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1021/acs.joc.4c02250
- Citations
- 3
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.75