Innovation in CRC Research: Targeting SPACA6P‐AS for Progression
The purpose of this research was to provide light on the functional role that the long noncoding RNA SPACA6P-AS plays in the biology of colorectal cancer (CRC). The presence of elevated SPACA6P-AS expression in colorectal cancer tissues is linked to advanced stages of the disease as well as a decreased overall survival rate. It has been demonstrated through knockdown tests conducted on CRC cell lines that SPACA6P-AS stimulates cell growth in both in vitro and in vivo settings. By acting as a competing endogenous RNA, SPACA6P-AS is able to modulate the levels of miR-339-5p and promote the proliferation of colorectal cancer cells by way of the miR-339-5p/FAM167AFAM167A signaling axis. Based on these findings, SPACA6P-AS is a promising candidate for both a prognostic marker and a therapeutic target in colorectal cancer.
Authors
- Guiyu Wang (ORCID: https://orcid.org/0000-0003-2501-5017)
- Guoqing Yan
- Yinghu Jin
- Tianyi Ma (ORCID: https://orcid.org/0000-0003-2736-7710)
- Hanqing Hu (ORCID: https://orcid.org/0000-0003-4920-1033)
- Qingchao Tang (ORCID: https://orcid.org/0000-0003-3874-5043)
- Song Wang (ORCID: https://orcid.org/0000-0003-1129-8044)
- Meng Wang (ORCID: https://orcid.org/0000-0002-8952-0840)
- Rui Huang (ORCID: https://orcid.org/0000-0002-7909-2002)
Institutions
- Harbin Medical University (CN)
- Chinese Academy of Sciences (CN)
- Zhejiang Cancer Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Biochemical and Molecular Toxicology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/jbt.70039
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University
- Second Affiliated Hospital of Harbin Medical University