Development of individualized risk assessment models for predicting post‐traumatic epilepsy 1 and 2 years after moderate‐to‐severe traumatic brain injury: A traumatic brain injury model system study
Using information available, acute-care, and year-1 post-injury data, parsimonious quantitative epilepsy prediction models following msTBI may facilitate timely evidence-based PTE prognostication within a 2-year period. We developed interactive web-based tools for testing prediction model external validity among independent cohorts. Individualized PTE risk may inform clinical trial development/design and clinical decision support tools for this population.
Authors
- Amy Kathleen Wagner (ORCID: https://orcid.org/0000-0003-3245-6523)
- Dominic DiSanto (ORCID: https://orcid.org/0000-0002-8815-2169)
- Ross Zafonte (ORCID: https://orcid.org/0000-0002-1050-796X)
- Jerzy P. Szaflarski (ORCID: https://orcid.org/0000-0002-5936-6627)
- Shannon B. Juengst (ORCID: https://orcid.org/0000-0003-4709-545X)
- Robert T. Krafty (ORCID: https://orcid.org/0000-0003-1478-6430)
- Cynthia Harrison‐Felix (ORCID: https://orcid.org/0000-0003-0489-4681)
- Mary Jo Pugh (ORCID: https://orcid.org/0000-0003-4196-7763)
- Nabil Awan (ORCID: https://orcid.org/0000-0001-6396-9095)
- Raj G. Kumar (ORCID: https://orcid.org/0000-0002-0858-3533)
- William C. Walker (ORCID: https://orcid.org/0000-0001-5813-3939)
- Kristen Dams-O’Connor (ORCID: https://orcid.org/0000-0002-2506-0216)
Institutions
- Brigham and Women's Hospital (US)
- Memorial Hermann Institute for Rehabilitation and Research Foundation (US)
- Craig Hospital (US)
- Harvard University (US)
- Emory University (US)
- University of Pittsburgh (US)
- Virginia Commonwealth University (US)
- University of Utah (US)
- Spaulding Rehabilitation Hospital (US)
- University of Alabama at Birmingham (US)
- Massachusetts General Hospital (US)
- VA Salt Lake City Healthcare System (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1111/epi.18210
- Citations
- 4
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- U.S. Department of Veterans Affairs
- Health Services Research and Development
- National Institute on Disability, Independent Living, and Rehabilitation Research
- Congressionally Directed Medical Research Programs