Late-Stage Functionalization of Guanine-Based Nucleosides, Nucleotides, and Oligonucleotide: Synthesis and Derivatization of Tricyclic Nucleoside Analogues
We report here the synthesis of tricyclic nucleoside analogues via acid-catalyzed cyclization of guanine with 1,1,3,3-tetramethoxypropane. The method enables the use of hydroxyl-unprotected antiviral drugs (acyclovir, ganciclovir, and penciclovir), guanosines, oligonucleotide, and triazole-linked nucleoside dimers as substrates. Nucleoside trimer and tetramer were synthesized by derivatization reactions.
Authors
- Ao-Di Ma
- Wen‐Wu Sun (ORCID: https://orcid.org/0000-0003-3687-9988)
- Bin Wu (ORCID: https://orcid.org/0000-0001-6048-4965)
- Weijia Chen
Institutions
- Minzu University of China (CN)
- State Ethnic Affairs Commission (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1021/acs.orglett.4c04024
- Citations
- 1
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Natural Science Foundation of China
- South-Central University for Nationalities
- Fundamental Research Funds for the Central Universities