Rapid diagnosis of bacterial vaginosis using machine-learning-assisted surface-enhanced Raman spectroscopy of human vaginal fluids
The accurate and rapid diagnosis of bacterial vaginosis (BV) is crucial due to its high prevalence and association with serious health complications, including increased risk of sexually transmitted infections and adverse pregnancy outcomes. Although widely used, traditional diagnostic methods have significant limitations in subjectivity, complexity, and cost. The development of a novel diagnostic approach that integrates SERS with ML offers a promising solution. The CNN model's high prediction accuracy, cost-effectiveness, and extraordinary rapidity underscore its significant potential to enhance the diagnosis of BV in clinical settings. This method not only addresses the limitations of current diagnostic tools but also provides a more accessible and reliable option for healthcare providers, ultimately enhancing patient care and health outcomes.
Authors
- Quan Yuan (ORCID: https://orcid.org/0000-0002-3085-431X)
- Muhammad Usman (ORCID: https://orcid.org/0000-0003-3083-9010)
- Hui-Jin Chen
- Jia‐Wei Tang (ORCID: https://orcid.org/0009-0003-2702-9946)
- Huimin Chen (ORCID: https://orcid.org/0000-0001-9315-3871)
- Yudong Zhang (ORCID: https://orcid.org/0009-0002-8023-8774)
- Liang Wang (ORCID: https://orcid.org/0000-0001-5339-7484)
- Xin‐Ru Wen
- Yu-Rong Tang
- Jie Chen (ORCID: https://orcid.org/0009-0003-2727-0289)
Institutions
- Edith Cowan University (AU)
- Xuzhou Medical College (CN)
- The University of Western Australia (AU)
- Shengli Oilfield Central Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1128/msystems.01058-24
- Citations
- 9
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 3.10
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province