Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin

With sufficient taxonomic resolution and sample size, this study critically evaluates new and published data on the gut microbiome in psoriasis patients. It shows that observed taxonomic changes in patients are modest and do not meet strict criteria for gut dysbiosis, at least in the large intestine. Instead, observed taxonomic changes in psoriasis patients can be explained by the microbial response to possible low-grade inflammation with unknown localization in the intestine and unclear impact on the host. The authors point out that published endoscopic data point to the small intestine as the site of gut inflammation. Therefore, further research focused on the small intestine would be informative to clarify the hypothetical gut-psoriasis link.

Authors

Institutions

Publication Details

Journal
Microbiology Spectrum
Published
2024-12-10
DOI
https://doi.org/10.1128/spectrum.01382-24
Citations
2
Primary Topic
Digestive system and related health
Type
article
Field-Weighted Citation Impact
1.10

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin

Anna Bogdanova, Л. Г. Данилов, Fanil Bilalov, Milyausha M. Yunusbaeva et al.
2 citations
Microbiology Spectrum
Digestive system and related health
1.10
article

Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin

Anna Bogdanova, Л. Г. Данилов, Fanil Bilalov, Milyausha M. Yunusbaeva, Bayazit Yunusbayev, Viktor P. Bogdanov, Г. А. Сергеев, Radick Altinbaev, Nadezhda Nadyrchenko
article en
2 citations

Abstract

With sufficient taxonomic resolution and sample size, this study critically evaluates new and published data on the gut microbiome in psoriasis patients. It shows that observed taxonomic changes in patients are modest and do not meet strict criteria for gut dysbiosis, at least in the large intestine. Instead, observed taxonomic changes in psoriasis patients can be explained by the microbial response to possible low-grade inflammation with unknown localization in the intestine and unclear impact on the host. The authors point out that published endoscopic data point to the small intestine as the site of gut inflammation. Therefore, further research focused on the small intestine would be informative to clarify the hypothetical gut-psoriasis link.

Microbiology SpectrumVol. 13(1)
Moscow Institute of Physics and Technology (RU), St Petersburg University (RU), ITMO University (RU), Institute of Physics and Technology (RU), Bashkir State Medical University (RU), Republican Oncological Clinical Dispensary (RU), Research Centre for Medical Genetics (RU), Institute of Higher Nervous Activity and Neurophysiology (RU), Medical Technologies (Czechia) (CZ)
Saint Petersburg State University, Russian Science Foundation, Ministry of Science and Higher Education of the Russian Federation
Life in Land
Openalex Percentile: Top 18%
Digestive system and related health
1.10
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.