Induction of Tier 2 HIV-Neutralizing IgA Antibodies in Rhesus Macaques Vaccinated with BG505.664 SOSIP
The parenteral vaccination of nonhuman primates with BG505.664 SOSIP generates HIV-1 tier 2 IgA nAbs in serum, including SOSIP-specific polymeric IgA, which appears to neutralize more efficiently than monomeric IgA or IgG. Mucosal delivery of this SOSIP or other stable Env trimers could generate locally synthesized polymeric IgA nAbs in mucosal tissues and secretions.
Authors
- Lisa A. Cavacini (ORCID: https://orcid.org/0000-0003-1417-8339)
- Rama Rao Amara (ORCID: https://orcid.org/0000-0002-6309-6797)
- Eric Hunter (ORCID: https://orcid.org/0000-0002-4273-8631)
- Bali Pulendran (ORCID: https://orcid.org/0000-0001-6517-4333)
- Traci Legere (ORCID: https://orcid.org/0000-0001-6393-719X)
- Prabhu S. Arunachalam (ORCID: https://orcid.org/0000-0003-0090-5689)
- Justin C. Smith (ORCID: https://orcid.org/0000-0001-7702-7920)
- Pamela A. Kozlowski (ORCID: https://orcid.org/0000-0001-9906-6234)
Institutions
- Emory University (US)
- University of Massachusetts Chan Medical School (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Stanford University (US)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3390/vaccines12121386
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- National Institutes of Health
- Weill Cornell Medical College
- National Institute of Allergy and Infectious Diseases