Distinct immune microenvironment of venous tumor thrombus in hepatocellular carcinoma at single-cell resolution
TAMs, especially C5aR+ TAMs, were enriched in PVTT. C5aR+ TAMs contribute to the development of PVTT and poor prognosis by reshaping the immunosuppressive environment.
Authors
- Yun‐Fan Sun (ORCID: https://orcid.org/0000-0001-9790-2761)
- Zefan Zhang (ORCID: https://orcid.org/0000-0001-5627-050X)
- Jianwen Cheng (ORCID: https://orcid.org/0000-0003-1321-5791)
- Xin‐Rong Yang (ORCID: https://orcid.org/0000-0002-2716-9338)
- Zheng Tang (ORCID: https://orcid.org/0000-0002-8604-5386)
- Jia Fan (ORCID: https://orcid.org/0000-0001-6386-1068)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-2118-1117)
- Yang Xu (ORCID: https://orcid.org/0009-0009-5454-7320)
- Pengxiang Wang (ORCID: https://orcid.org/0000-0003-3483-6810)
- Kaiqian Zhou (ORCID: https://orcid.org/0000-0002-2763-5976)
- Yucheng Zhong (ORCID: https://orcid.org/0000-0002-0341-655X)
- Minfang Song (ORCID: https://orcid.org/0000-0003-4685-1823)
- Liye Zhang (ORCID: https://orcid.org/0000-0002-8829-0588)
- Wei Zhu
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Cancer Institute (WIA) (IN)
- ShanghaiTech University (CN)
- Ministry of Education (SA)
- Zhejiang Lab (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Ministry of Education (ET)
- Shanghai Clinical Research Center (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1097/hep.0000000000001182
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.17