Synthesis, Antibacterial Evaluation and Study Molecular Docking of New derivatives from sulfapyridine

Sulfa pyridine is a sulfa-derived antibiotic. It works to inhibit the activity and reproduction of bacterial cells, by inhibiting the production of some enzymes that bacteria need for their growth and activity. Therefore, in this research, we decided to increase the effectiveness of the Sulfa pyridine compound by adding some groups such as azomethine, as well as preparing some derivatives of thiazolidinone and derivatives , thiazine, hydroquinazolone, and oxazepine, Then evaluating the effectiveness of some prepared derivatives against two types of gram-negative and gram-positive bacteria, such as E. coli and Staphylococcus aureus and molecular docking study against skin cancer .