Microwave-Assisted Synthesis of Five and Seven-Membered Heterocycles from Ibuprofen and Study Their Biological Activity

In order to reduce the ulcerogenic effect of ibuprofen carboxylic group has been converted into 7-membered and 5-membered heterocyclic rings. Various 1,3-oxazepane (A3-A6) imidazoldine-2,3-indole (A7-A10) Derivatives of ibuprofen were prepared by cyclization under various reaction conditions in a very good yield. The microbial inhibitory effect of the new agents has been assessed in vitro against Gram-positive and Gram-negative bacteria activity.By creating ibuprofen derivatives, our goal in the current study is to improve the antimycobacterial profile at lower concentrations. The synthesis of derivatives of ibuprofen and their antibacterial and antimycobacterial properties are the subjects of this paper.