New Sensitive Spectrophotometric Method for Methyldopa Determination in Different Pharmaceutical Samples

Methyldopa (M. dopa) drug concentration in pharmaceutical and pure forms is determined using a simple spectrophotometric method. In this work, the medication is first oxidized using an excess of N-bromosuccinimide (NBS), and then it is reduced with 3,3-diaminobenzidine (DAB). At 513 nm, the resultant chemical is detected. Beer's law was found to be applicable within concentration ranges of 0.5-10 mg/L, with a molar absorptivity of 25.87×103 L mol-1 cm-1. The common excipients and additives did not interfere in their determination of both methods. The proposed method was effectively utilized to analyze the mentioned drugs in different forms of dosages.