Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity

This research includes prepeared of some new heterocyclic compounds from 2-hydroxy napthaldehyde with 2-amino thiazol , 2-amino thiazol reacted with 2-hydroxy napthaldehyde , to produce shiff base derivative (R),(R) using to synthesis of some new heterocyclic derivatives by reactions and reactant with types solvent and materials to synthesis heterocyclic membered ring , first step : Involved synthesis of seven heterocyclic compounds by reacting (R) with phthalic ,succinic and malic anhydride respectfully to prepeared oxazepine compounds (R1,R2,R3) . Second step involves preparing of five- heterocyclic derivatives by reacting (R) with amino acid glycine and thyrocine in tetra hydro furan to prepare (R4,R5).Third step includes preparing of four heterocyclic compounds β-lactam(S6). All the compounds were characterized by FT-IR ,H1NMR,13CNMR .Also compounds were studied the measurement antibacterial activity.

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Publication Details

Journal
Journal of Kufa for Chemical Sciences
Published
2024-11-01
DOI
https://doi.org/10.36329/jkcm/2024/v3.i3.15932
Primary Topic
Synthesis of β-Lactam Compounds
Type
article
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article

Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity

Rusul Ali Muhammad, Rajaa Abdulameer Ghafil
Journal of Kufa for Chemical Sciences
Synthesis of β-Lactam Compounds
article

Synthesis, Identification some of new heterocyclic Compounds Derivatives and study of the biological Activity

Rusul Ali Muhammad, Rajaa Abdulameer Ghafil
article en

Abstract

This research includes prepeared of some new heterocyclic compounds from 2-hydroxy napthaldehyde with 2-amino thiazol , 2-amino thiazol reacted with 2-hydroxy napthaldehyde , to produce shiff base derivative (R),(R) using to synthesis of some new heterocyclic derivatives by reactions and reactant with types solvent and materials to synthesis heterocyclic membered ring , first step : Involved synthesis of seven heterocyclic compounds by reacting (R) with phthalic ,succinic and malic anhydride respectfully to prepeared oxazepine compounds (R1,R2,R3) . Second step involves preparing of five- heterocyclic derivatives by reacting (R) with amino acid glycine and thyrocine in tetra hydro furan to prepare (R4,R5).Third step includes preparing of four heterocyclic compounds β-lactam(S6). All the compounds were characterized by FT-IR ,H1NMR,13CNMR .Also compounds were studied the measurement antibacterial activity.

Journal of Kufa for Chemical SciencesVol. 3(3)
Openalex Percentile: Top 83%
Synthesis of β-Lactam Compounds
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