Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer
We show that the lipidomic profile of CRC tumours exhibits a distinct pro-inflammatory bias with a deficiency of endogenous resolving mediators secondary to defective lipid class switching. These observations pave the way for 'resolution medicine', a novel therapeutic approach for inducing or providing resolvins to mitigate the chronic inflammation driving cancer growth and progression.
Authors
- Mingli Yang (ORCID: https://orcid.org/0000-0002-4781-690X)
- Jetsen A. Rodriguez-Silva (ORCID: https://orcid.org/0000-0003-1855-7678)
- Ramani Soundararajan (ORCID: https://orcid.org/0000-0001-6408-2840)
- Gunjan Upadhyay (ORCID: https://orcid.org/0009-0002-2669-1607)
- Divyavani Gowda (ORCID: https://orcid.org/0000-0001-8102-1302)
- Carolina Martinez (ORCID: https://orcid.org/0009-0008-9731-2938)
- Timothy J Yeatman
- Shu‐Ping Hui (ORCID: https://orcid.org/0000-0001-9973-6461)
- Ashley J. Alden (ORCID: https://orcid.org/0009-0007-8920-2467)
- Paul M. Cavallaro (ORCID: https://orcid.org/0000-0003-3594-5453)
- Robert J. Coffey (ORCID: https://orcid.org/0000-0002-2180-3844)
- Ganesh V. Halade (ORCID: https://orcid.org/0000-0002-5351-9354)
- Michelle M. Maurin (ORCID: https://orcid.org/0009-0005-4777-2504)
- Andreas Karachristos (ORCID: https://orcid.org/0000-0001-5773-5209)
- Michael Nebozhyn (ORCID: https://orcid.org/0000-0001-8835-7714)
- Michael J. Schell (ORCID: https://orcid.org/0000-0003-4594-6601)
- Matthew L. Anderson (ORCID: https://orcid.org/0000-0002-2081-4672)
- Andrey Loboda (ORCID: https://orcid.org/0000-0003-4239-184X)
- Lance Pflieger (ORCID: https://orcid.org/0000-0003-2237-5674)
- Warren Jackson Pledger (ORCID: https://orcid.org/0000-0001-5306-7506)
- Jorge Marcet (ORCID: https://orcid.org/0000-0003-3728-8741)
- Allen P. Chudzinski (ORCID: https://orcid.org/0000-0002-2877-3772)
- Heiman Wang (ORCID: https://orcid.org/0009-0007-5799-8982)
- Timothy M. Nywening
- Punith M. Sundaraswamy (ORCID: https://orcid.org/0000-0003-2712-7581)
- Domenico Coppola
- Robert David Bennett (ORCID: https://orcid.org/0000-0002-1336-970X)
- Siddabasave Gowda B. Gowda
- Noah Jhad Levine
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Buck Institute for Research on Aging (US)
- Hokkaido University (JP)
- University of South Florida (US)
- Tampa General Hospital (US)
- Moffitt Cancer Center (US)
- Florida Digestive Health Specialists (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Gut
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1136/gutjnl-2024-332535
- Citations
- 31
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.84
Funders
- National Institute for Health and Care Research
- Israel National Institute for Health Policy Research
- National Institutes of Health
- National Cancer Institute