Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8 <sup>+</sup> T cells by granzyme B and perforin
ST8Sia1 is a potential diagnostic biomarker and therapeutic target for READ, enhancing CD8<sup>+</sup> T cell function and possibly improving patient outcomes through cellular immunotherapy.
Authors
- Yeli Wang
- Yanchao Pang
- Xiao Xiao (ORCID: https://orcid.org/0000-0002-4328-0634)
- Yu Yao (ORCID: https://orcid.org/0000-0003-2246-0721)
- Chang Zhang (ORCID: https://orcid.org/0000-0002-5443-8951)
- Leilei Hao (ORCID: https://orcid.org/0009-0002-7276-3261)
Institutions
- Qingdao University (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1080/07853890.2024.2439539
- Citations
- 5
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.20