Incidence and Outcomes of Patients With Mismatch Repair Deficient Rectal Cancer Operated in 2016: A Nationwide Cohort From The Netherlands
In this population-based cohort, 2.8% of rectal cancers in which MMR-status was determined were subtyped as dMMR. Surprisingly, dMMR was associated with higher pathological complete response rate to neoadjuvant (chemo) radiotherapy than pMMR. MMR-status did not impact oncological outcomes.
Authors
- Corrie A.M. Marijnen (ORCID: https://orcid.org/0000-0003-0189-5953)
- Tania C. Sluckin (ORCID: https://orcid.org/0000-0002-5913-2644)
- M. Lange (ORCID: https://orcid.org/0000-0002-9874-1119)
- Miranda Kusters
- Myriam Chalabi (ORCID: https://orcid.org/0000-0002-8607-6174)
- Cornelis Verhoef
- Tjeerd S. Aukema
- Pieter J. Tanis (ORCID: https://orcid.org/0000-0002-3146-3310)
- Cornelis R. C. Hogewoning (ORCID: https://orcid.org/0000-0003-4683-8741)
- Sanne-Marije J.A. Hazen (ORCID: https://orcid.org/0000-0001-8372-1986)
- Pétur Snæbjörnsson (ORCID: https://orcid.org/0000-0002-1086-8108)
- Regina G. H. Beets‐Tan (ORCID: https://orcid.org/0000-0002-8533-5090)
- Eline G M van Geffen
Institutions
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- Maastricht University (NL)
- St. Antonius Ziekenhuis (NL)
- Oncode Institute (NL)
- Haga Hospital (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Maastro Clinic (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Clinical Colorectal Cancer
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.clcc.2024.12.003
- Citations
- 8
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- KWF Kankerbestrijding