New Benzofuran–Pyrazole-Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, DNA Gyrase B Inhibition, and In Silico Studies
The benzofuran-pyrazole-based compounds, particularly compound <b>9</b>, show great potential as new antimicrobial agents due to their broad-spectrum activity and potent DNA gyrase B inhibition. These findings support further development and optimization of these compounds for clinical applications.
Authors
- Hassan M. Awad (ORCID: https://orcid.org/0000-0002-8744-5496)
- Somaia S. Abd El‐Karim (ORCID: https://orcid.org/0000-0002-3463-3047)
- Asmaa Negm El-Dein (ORCID: https://orcid.org/0000-0002-8177-925X)
- Mohamed Kandeel El-Ashrey (ORCID: https://orcid.org/0000-0002-3548-3888)
- Yasmin M. Syam (ORCID: https://orcid.org/0000-0003-1183-0424)
- Sameh H. Abdelwahed (ORCID: https://orcid.org/0000-0002-3445-4065)
- Manal M. Anwar (ORCID: https://orcid.org/0000-0002-3967-4534)
- Hamad M. Alkahtani (ORCID: https://orcid.org/0000-0002-6983-8587)
Institutions
- Cairo University (EG)
- Prairie View A&M University (US)
- King Saud University (SA)
- National Research Centre (EG)
- King Salman International University
- Texas A&M University (US)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3390/ph17121664
- Citations
- 8
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- King Saud University