Metabolic analysis of three-dimensional cultured gastrointestinal cancer cells suggests that L-arginine inhibits tumor growth by affecting the urea cycle
Arginine affected urea cycle metabolism, thereby decreasing CAA, which is required for pyrimidine nucleotide synthesis. These findings provide insight into the mechanism underlying the anticancer effects of arginine.
Authors
- Hirohito Ishigaki (ORCID: https://orcid.org/0000-0002-5249-8598)
- Naoko Taniura
- Eri Tanaka (ORCID: https://orcid.org/0000-0002-0895-8323)
- Yusuke Kageyama (ORCID: https://orcid.org/0000-0002-3382-9881)
- Mai Noujima
- Ken‐ichi Mukaisho (ORCID: https://orcid.org/0000-0002-0488-0100)
- Ryoji Kushima (ORCID: https://orcid.org/0000-0002-3016-2698)
- Takahisa Nakayama
Institutions
- Shiga University of Medical Science (JP)
Publication Details
- Journal
- Pathobiology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1159/000543006
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00