Validating and utilizing dried blood spots for family screening: Screening Programme Providing Outreach for Testing Hereditary Angioedema (SPPOT-HAE)
This is the first study to validate measurement of fC1-INH using DBS in C1-INH-HAE with conventional assays. An outreach program using DBS is a promising strategy overcoming previous barriers of family screening. Further large-scale, multicenter studies are required to establish the role of DBS, compare cost-effectiveness with prior strategies, and maximize diagnosis in resource-constrained countries.
Authors
- Jane C. Y. Wong (ORCID: https://orcid.org/0000-0002-6719-6787)
- Valerie Chiang (ORCID: https://orcid.org/0000-0001-9250-967X)
- Philip Hei Li (ORCID: https://orcid.org/0000-0002-9155-9162)
- Elaine Lee (ORCID: https://orcid.org/0000-0002-0627-5297)
- Jackie S. H. Yim
- Weihong Shi
- Dorothy L.Y. Lam
Institutions
- Queen Mary Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jacig.2024.100381
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- CSL Behring
- Takeda Pharmaceutical Company