Development and Validation of a Method for the Simultaneous Estimation of Diltiazem and Lidocaine Using Ultraviolet-Visible Spectroscopy

Diltiazem and lidocaine are two drugs that are used in the treatment of anal fissures. Both of these medications are employed. The objective of this study is to devise analytical procedures that are uncomplicated, precise, and accurate for the purpose of simultaneously estimating the levels of these two drugs. To be more specific, the UV spectrophotometric approach was developed specifically for the aim of being evaluated. In terms of solubility in methanol, both carpets had a good degree of solubility, and linearity was observed between 10 µg/ml and 50 µg/ml for both Lidocaine and Diltiazem. The maximum wavelengths (λmax) of these carpets were measured to be 262 nm and 275 nm, respectively. Comparatively, the recovery percentages for diltiazem and lidocaine were 106% and 96.6%, respectively, when compared to one another. The measurements revealed that the correlation coefficients for diltiazem and lidocaine were 0.999 and 0.996, respectively.