Relationship of Serum Uric Acid and Serum Creatinine Levels with Total Count of WBC in Acute Leukaemia

Background: Leukaemia is uncontrolled proliferation of white blood cells caused by mutation of myelogenous or lymphogenous cells which are usually characterized by increased number of white blood cells in the blood. Leukaemia accounts for about four percent of all death from malignant disease. The incidence of acute leukaemia is about 10 per lac per year. Acute leukaemia can occur at any age. The cause of leukaemia is unknown in most patients. Serum uric acid and creatinine levels increased and positively correlated with total count of WBC in acute leukaemic patients. Objective: Objective of our study is to observe the relationship of serum uric acid and creatinine levels with total count of WBC in pre-chemotherapy stage of acute leukaemic patients. Method: Total 60 of acute leukaemia patients were included in this study. Among them, 30 patients’ WBC count were below 50,000/cmm and 30 patients’ WBC count were above 50,000/cmm. Result: Majority patients were male. Serum uric acid and creatinine levels were significantly higher in acute leukaemic patients with WBC count above 50,000/cu mm of blood than those with total count of WBC below 50,000/cmm.