Therapeutic perspectives for prion diseases in humans and animals

Prion diseases are a group of fatal neurodegenerative disorders affecting several mammals including humans, cattle, cervids, sheep, goats, and others [1-3]. These diseases are driven by the misfolding of the cellular prion protein (PrP C ) into -sheet rich structures. The diseaseassociated prion, termed PrP Sc , is prone to aggregation as well as neurotoxic Prion diseases can be associated with mutations in the prion protein gene (PRNP), induced by the exposure to prion-contaminated materials, or arise sporadically