Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischaemic injury involves direct activation of mitochondrial sirtuin 3
These data demonstrate that 19,20-EDP-mediated cardioprotective mechanisms against ischaemia and IR injury involve mitochondrial SIRT3, resulting in improved cardiac efficiency.
Authors
- Wesam Bassiouni (ORCID: https://orcid.org/0000-0001-8410-3960)
- Hao Zhang (ORCID: https://orcid.org/0000-0003-4080-3222)
- Zamaneh Kassiri (ORCID: https://orcid.org/0000-0002-9357-0912)
- Gavin Y. Oudit (ORCID: https://orcid.org/0000-0002-9154-9028)
- John M. Seubert (ORCID: https://orcid.org/0000-0003-0764-3933)
- Darryl C. Zeldin (ORCID: https://orcid.org/0000-0002-2087-7307)
- Evangelos D. Michelakis (ORCID: https://orcid.org/0000-0003-0787-7721)
- John R. Ussher (ORCID: https://orcid.org/0000-0001-9574-5707)
- Khaled Barakat (ORCID: https://orcid.org/0000-0002-3567-7279)
- Marawan Ahmed (ORCID: https://orcid.org/0000-0003-1894-1792)
- Ahmed M. Darwesh
- Robert Valencia (ORCID: https://orcid.org/0000-0002-9825-7095)
- K. Lockhart Jamieson (ORCID: https://orcid.org/0000-0003-3957-8988)
- Matthew L. Edin (ORCID: https://orcid.org/0000-0002-7042-500X)
- Yongneng Zhang (ORCID: https://orcid.org/0000-0002-0791-9381)
- Gary D. Lopaschuk (ORCID: https://orcid.org/0000-0003-1010-0454)
- Andy Huang (ORCID: https://orcid.org/0000-0002-9441-6247)
- Liye Fang (ORCID: https://orcid.org/0000-0001-7566-7916)
- Tariq Altamimi (ORCID: https://orcid.org/0000-0001-6543-9805)
- Faqi Wang
- Keshav Gopal (ORCID: https://orcid.org/0000-0002-3320-2990)
Institutions
- University of Alberta (CA)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1093/cvr/cvae252
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- Heart and Stroke Foundation of Canada
- Killam Trusts
- Alberta Innovates
- National Institutes of Health
- Canadian Institutes of Health Research