Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline
CUMS-induced behavioural changes and the HPA axis dysregulation could be induced by the increased levels of KYNA via KMO suppression. KYNA plays an important role in the pathophysiology of MDD as an α7nACh antagonist. Therefore, α7nACh receptor is an attractive therapeutic target for MDD.
Authors
- Kuniaki Saito (ORCID: https://orcid.org/0000-0001-8233-9283)
- Masaya Hasegawa (ORCID: https://orcid.org/0009-0002-5125-314X)
- Akihiro Mouri (ORCID: https://orcid.org/0000-0003-3833-4041)
- Kazuo Kunisawa (ORCID: https://orcid.org/0000-0002-4786-9681)
- Honomi Ando (ORCID: https://orcid.org/0009-0002-9253-209X)
- Bolati Wulaer (ORCID: https://orcid.org/0000-0002-0864-9870)
- Takatoshi Sakata
- Hitomi Kurahashi
- Suwako Fujigaki
- Hisayoshi Kubota (ORCID: https://orcid.org/0000-0002-0078-3418)
- Hidetsugu Fujigaki (ORCID: https://orcid.org/0000-0001-9655-1074)
- Taku Nagai (ORCID: https://orcid.org/0000-0001-5050-7748)
- Toshitaka Nabeshima
- Yasuko Yamamoto (ORCID: https://orcid.org/0000-0003-2243-2800)
Institutions
- Fujita Health University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1111/bph.17407
- Citations
- 14
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- Takeda Science Foundation
- Japan Science and Technology Corporation
- Smoking Research Foundation
- Fujita Health University
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency