Time-Restricted Feeding Reinforces Gut Rhythmicity by Restoring Rhythms in Intestinal Metabolism in a Jetlag Mouse Model
This pioneering transcriptomic study demonstrates that TRF acts as a robust entrainer during chronic jetlag, realigning disturbances in the circadian clock and the transcriptome involved in metabolic functions in the jejunal mucosa. Enteroids can replicate the rhythmic accumulation of neutral lipids dependent on the jejunal epithelial clock, enabling these functions to be studied in vitro.
Authors
- Theo Thijs (ORCID: https://orcid.org/0000-0001-5226-2633)
- Inge Depoortere (ORCID: https://orcid.org/0000-0002-0289-2175)
- Guillaume Vanotti
- Louis Desmet (ORCID: https://orcid.org/0000-0002-1877-0922)
- Mona Farhadipour (ORCID: https://orcid.org/0000-0002-8454-2856)
- Hui Leng (ORCID: https://orcid.org/0000-0002-0303-042X)
Institutions
- KU Leuven (BE)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101440
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- China Scholarship Council