Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ<sup>2</sup>‐Isoxazolines via a Formal C(sp<sup>3</sup>)−H Functionalization
Abstract The discovery of a dehydrogenative photoredox catalyzed formal C(sp 3 )−H intramolecular cyclization of indolyl‐oximes to generate indolyl Δ 2 ‐isoxazolines is reported. In contrast to the current state‐of‐the‐art, the reaction avoids the use of super stoichiometric chemical oxidants and high reaction temperatures and is proposed to operate via two sequential single electron oxidation events.
Authors
- James A. Rossi‐Ashton (ORCID: https://orcid.org/0000-0002-0989-2506)
- William P. Unsworth (ORCID: https://orcid.org/0000-0002-9169-5156)
- Wade F. Petersen (ORCID: https://orcid.org/0000-0003-3215-5560)
- Richard J. Payne (ORCID: https://orcid.org/0000-0002-3618-9226)
- Farhaan Dobah (ORCID: https://orcid.org/0000-0003-3678-8787)
- Jonathan Da Luz (ORCID: https://orcid.org/0009-0000-6332-1483)
Institutions
- The University of Sydney (AU)
- Australian Research Council (AU)
- University of Cape Town (ZA)
- University of Manchester (GB)
- ARC Centre of Excellence for Innovations in Peptide and Protein Science (AU)
- University of York (GB)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1002/ejoc.202401369
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00