Visible-Light-Mediated Nucleophilic Addition of Alkene with Aldehyde: Synthesis of Secondary Alcohols
Herein, a photocatalytic strategy for the synthesis of secondary alcohols by nucleophilic addition of an alkene with an aldehyde is described. This operationally simple methodology opens an approach for the synthesis of alcohols using commercially available reagents in moderate to excellent yields. Mechanistic studies indicate that the formation of the radical anion from alkene via single-electron transfer is the key step in this reaction.
Authors
- Yunyun Du
- Chao Shen (ORCID: https://orcid.org/0000-0001-8826-5879)
- Min Wang (ORCID: https://orcid.org/0000-0002-8776-1560)
- Donghao Wang (ORCID: https://orcid.org/0000-0003-3038-8379)
- Jiabin Shen (ORCID: https://orcid.org/0009-0009-0908-8946)
- D. Hu
- Huu Phuong Dang
- Zhen Liang (ORCID: https://orcid.org/0000-0002-5242-4644)
Institutions
- Hangzhou Normal University (CN)
- Zhejiang Shuren University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1021/acs.orglett.4c03819
- Citations
- 11
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- National Natural Science Foundation of China
- Zhejiang Shuren University