Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing
Insights into the heterogeneity and transcriptional patterns of sarcoma cells may explain the challenges in treating primary cardiac angiosarcoma (PCAS) using the current therapeutic modalities. Characterization of the immune microenvironment revealed significant immunosuppression mediated by specific myeloid cell populations (SPP1+ and OLR1+ macrophages). Identification of mitochondrial dysfunction in immune cells within the PCAS microenvironment, particularly the notable downregulation of the MTRNR2L12 protein, suggests a new avenue for therapeutic targeting.
Authors
- Haoyang Li (ORCID: https://orcid.org/0000-0002-4854-3317)
- Jin‐Ling Huo (ORCID: https://orcid.org/0000-0003-0819-4586)
- Hongfei Xu (ORCID: https://orcid.org/0000-0002-8891-2463)
- Hongda Ding (ORCID: https://orcid.org/0000-0002-9896-0661)
- Fengpu He
- Yiming Ni (ORCID: https://orcid.org/0000-0002-2909-6734)
- Firyuza Husanova
- Weidong Li (ORCID: https://orcid.org/0000-0001-5384-4838)
- Miao Chen (ORCID: https://orcid.org/0000-0002-3538-8231)
- Yaqi Ma
- Xiao Tian (ORCID: https://orcid.org/0000-0001-6294-6342)
- Wenting Zhao (ORCID: https://orcid.org/0000-0002-5769-6331)
- Zhen Wang (ORCID: https://orcid.org/0009-0004-5437-1103)
- Liang Ma
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/ctm2.70113
- Citations
- 3
- Primary Topic
- Cardiac tumors and thrombi
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- National Natural Science Foundation of China