Continuous Flow Synthesis of α‐Chloroketones from Esters
Abstract Herein, we report a novel and practical strategy to access α‐chloroketones from esters bearing diverse (hetero)aromatic, aliphatic, alkynyl and alkenyl substituents with transient chloromethyllithium under continuous flow conditions. This highly chemoselective method enables a fast (on a time scale of <5 s), efficient and straightforward access to a broad substrate scope (up to 99% yield) with a remarkable throughput of ∼10.6 g/h.
Authors
- Massimiliano Forcato
- Laëtitia Chausset‐Boissarie (ORCID: https://orcid.org/0000-0002-9549-057X)
- Maxime Manneveau
- Thomas Poisson (ORCID: https://orcid.org/0000-0002-0503-9620)
- Philippe Jubault (ORCID: https://orcid.org/0000-0002-3295-9326)
- Laurence Brassart (ORCID: https://orcid.org/0000-0001-7966-750X)
- Philippe Huez
- Julien Legros (ORCID: https://orcid.org/0000-0002-4807-7897)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Normandie Université (FR)
- Laboratoire Génie Industriel (FR)
- Pharmac (NZ)
- Laboratoire COBRA (FR)
- Université de Rouen Normandie (FR)
- Institut National des Sciences Appliquées Rouen Normandie (FR)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-12-10
- DOI
- https://doi.org/10.1002/adsc.202401438
- Citations
- 4
- Primary Topic
- Chemical Synthesis and Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- Indian National Science Academy
- Agence Nationale de la Recherche
- Centre National de la Recherche Scientifique
- Université de Rouen
- Institut Carnot Santé Animale
- Région Normandie