Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption
In this study, we investigated the role of the histone methyltransferase NSD2 in preventing intestinal barrier disruption by sustaining taurine biosynthesis. NSD2 levels were reduced in both human specimens and mouse models of IBD. We demonstrate that NSD2 loss hinders the process of taurine synthesis in intestinal cells, leading to increased intestinal inflammation. Supplementation with taurine significantly relieved the symptoms caused by NSD2 deficiency. These data suggest that maintenance of NSD2-mediated taurine biosynthesis is vital for preserving the intestinal barrier and attenuating inflammation.
Authors
- Ningyuan Liu (ORCID: https://orcid.org/0000-0002-1877-6136)
- Xiuying Xiao (ORCID: https://orcid.org/0000-0002-9873-0380)
- Wei‐Qiang Gao (ORCID: https://orcid.org/0000-0002-0959-2570)
- Hanyu Rao (ORCID: https://orcid.org/0000-0003-1286-8707)
- Rebiguli Aji
- Li Li (ORCID: https://orcid.org/0000-0003-2342-3658)
- Ziyi Wang (ORCID: https://orcid.org/0000-0003-4901-3438)
- Yue Xu (ORCID: https://orcid.org/0000-0002-1137-0272)
- Chunxiao Ma
- Wei Zhang (ORCID: https://orcid.org/0009-0001-4419-4551)
- Xiangjun Meng
- Wenxin Feng
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Veterinary Research Institute (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/ctm2.70128
- Citations
- 1
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Jiao Tong University
- National Key Research and Development Program of China