Phenotypic Versus Genetic Mismatch of BMI and Type 2 Diabetes: Evidence From Two Prospective Cohort Studies
Social developments have fostered an "obesogenic environment" that exacerbated phenotypic versus genetic mismatch of BMI (BMI-PGM) and the risk of type 2 diabetes. The study quantified BMI-PGM and examined its association with type 2 diabetes independent of BMI and other conventional factors. The risk of type 2 diabetes was lower in the discordantly low BMI-PGM group and higher in the discordantly high BMI-PGM group, with concordant BMI-PGM group as reference. These findings indicate the potential to reassess type 2 diabetes risk by quantifying BMI-PGM on individual levels.
Authors
- Shuo Gong (ORCID: https://orcid.org/0000-0001-9603-8158)
- Ling Yang (ORCID: https://orcid.org/0000-0001-5750-6588)
- Aolin Li (ORCID: https://orcid.org/0000-0003-0988-6787)
- Dianjianyi Sun (ORCID: https://orcid.org/0000-0003-3651-6693)
- Canqing Yu (ORCID: https://orcid.org/0000-0002-0019-0014)
- Iona Y. Millwood (ORCID: https://orcid.org/0000-0002-0807-0682)
- Robin G. Walters (ORCID: https://orcid.org/0000-0002-9179-0321)
- Jun Lv (ORCID: https://orcid.org/0000-0001-7916-3870)
- Huaidong Du (ORCID: https://orcid.org/0000-0002-9814-0049)
- Xiaoming Yang (ORCID: https://orcid.org/0000-0002-4076-3569)
- Pei Pei (ORCID: https://orcid.org/0009-0008-1893-0712)
- Yiping Chen (ORCID: https://orcid.org/0000-0002-4973-0296)
- Zhengming Chen (ORCID: https://orcid.org/0000-0001-6423-105X)
- Wei Hou (ORCID: https://orcid.org/0000-0003-1441-0708)
- Junshi Chen (ORCID: https://orcid.org/0000-0001-5530-1343)
- Liming Li (ORCID: https://orcid.org/0000-0002-2898-6188)
Institutions
- Peking University (CN)
- University of Oxford (GB)
- Ministry of Education (RO)
- Office of Readiness and Response (US)
- China National Center for Food Safety Risk Assessment (CN)
- Qingdao Municipal Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Diabetes
- Published
- 2024-12-10
- DOI
- https://doi.org/10.2337/db24-0736
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Medical Research Council