Partial activation of salt-inducible kinase 3 delays the onset of wakefulness and alleviates hypersomnia due to the lack of protein kinase A-phosphorylation site
Our results suggest that the peak onset of wakefulness is sensitive to disturbed kinase activity of SIK3, and the relationship between phosphorylation at T221 and S551 is critical for regulating sleep need.
Authors
- Hiromasa Funato (ORCID: https://orcid.org/0000-0002-2787-9700)
- Masashi Yanagisawa (ORCID: https://orcid.org/0000-0002-7358-4022)
- Tomoyuki Fujiyama (ORCID: https://orcid.org/0000-0001-6420-2283)
- Shinya Nakata
- Noriko Hotta-Hirashima (ORCID: https://orcid.org/0009-0001-6998-025X)
- Haruna Komiya
- Chika Miyoshi (ORCID: https://orcid.org/0000-0002-7109-1777)
- Fuyuki Asano (ORCID: https://orcid.org/0000-0002-9287-2011)
- Aya Ikkyu (ORCID: https://orcid.org/0009-0001-0510-1842)
- Seiya Mizuno (ORCID: https://orcid.org/0000-0002-6740-5817)
- Miyo Kakizaki
- Satoru Takahashi (ORCID: https://orcid.org/0000-0002-8540-7760)
- Motoki Juichi
- Daiki Komine
Institutions
- Toho University (JP)
- University of Tsukuba (JP)
- Tsukuba Medical Center Hospital (JP)
- The University of Texas Southwestern Medical Center (US)
- Tsukuba International University (JP)
Publication Details
- Journal
- SLEEP
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/sleep/zsae279
- Citations
- 3
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.03