Functional role of the biofilm regulator CsgD in Salmonella enterica sv. Typhi
We demonstrate that although CsgD-regulated curli and cellulose production were partially restored, the introduction of the <i>S.</i> Typhimurium <i>csgD</i> did not induce the Rdar colony morphology. Interestingly, we show that CsgD does not have a significant role in S. Typhi biofilm formation, as biofilm-forming capacities depend more on the isolate than the CsgD regulator. This data suggests the presence of an alternative biofilm regulatory process in this human-restricted pathogen.
Authors
- Baileigh Laipply
- Juan F. González (ORCID: https://orcid.org/0000-0002-4568-7200)
- Victoria A. Sadowski (ORCID: https://orcid.org/0000-0002-9621-2387)
- John S. Gunn (ORCID: https://orcid.org/0000-0003-2848-8346)
- Matthew Price (ORCID: https://orcid.org/0000-0002-7344-1603)
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University (US)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-12-10
- DOI
- https://doi.org/10.3389/fcimb.2024.1478488
- Citations
- 6
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Temple University