Dermal cellular senescence and EndMT in patients with systemic sclerosis undergoing cyclophosphamide or aHSCT treatment
Both aHSCT and iv CYC in dcSSc reduced skin thickening clinically and attenuated EndMT, but affected cellular senescence not significantly different. EndMT and uPAR were associated with fibro-remodelling activity, whereas senescence, CTGF, uPAR and vascularity were associated with treatment response.
Authors
- Jeska K de Vries‐Bouwstra (ORCID: https://orcid.org/0000-0002-5624-1415)
- Yu‐Hsiang Chiu (ORCID: https://orcid.org/0000-0001-7925-895X)
- Roel Goldschmeding (ORCID: https://orcid.org/0000-0002-5471-1153)
- Julia Spierings (ORCID: https://orcid.org/0000-0002-2546-312X)
- J.M. van Laar (ORCID: https://orcid.org/0000-0001-8221-1669)
- Marijke van Dijk
Institutions
- Tri-Service General Hospital (TW)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- The Royal Free Hospital (GB)
- University Medical Center Utrecht (NL)
- University College London (GB)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/rheumatology/keae660
- Citations
- 1
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Eli Lilly and Company
- Universitair Medisch Centrum Utrecht
- Leids Universitair Medisch Centrum