Synovial transcriptome-wide association study implicates novel genes underlying rheumatoid arthritis risk
Our study is the first to model gene expression in synovial tissue, uncovering novel genetic determinants of rheumatoid arthritis (RA). This advancement not only deepens our understanding of RA's genetic architecture, but also offers promising avenues for targeted therapies and drug repurposing.
Authors
- Shouye Hu (ORCID: https://orcid.org/0000-0003-3411-8771)
- Feng Jiang (ORCID: https://orcid.org/0000-0002-9726-5720)
- Shi Yao (ORCID: https://orcid.org/0000-0002-4574-8106)
- Yan Guo (ORCID: https://orcid.org/0000-0002-7364-2392)
- Zhi Yang (ORCID: https://orcid.org/0000-0002-6577-8943)
- Yakang Wang (ORCID: https://orcid.org/0000-0002-1403-9032)
- Tie-Lin Yang
- Chang-Yi He
- Huimiao Song
- Hao Wu (ORCID: https://orcid.org/0000-0001-9647-9180)
- Wen Tian (ORCID: https://orcid.org/0000-0003-2418-5209)
- Hui-Wu Gao
Institutions
- Xi'an Honghui Hospital (CN)
- Ministry of Education (BD)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/rheumatology/keae654
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Natural Science Foundation of China
- Servier
- Yakult Bio-Science Foundation
- Fundamental Research Funds for the Central Universities