P129 Inflammation and autoimmunity dynamics in psoriasis

Abstract Psoriasis is a chronic, immune-mediated, inflammatory disorder that extends beyond the skin, and the concept of psoriatic disease emphasizes the systemic inflammation. Specific immunologic pathways responsible for the development of psoriasis have been discovered, but no certain biomarkers where directly associated with this entity. Psoriatic disease, antinuclear antibodies (ANA) and inflammation markers have been linked in different studies for assessment of disease course during biologic therapy. Our objective was to evaluate ANA profile and the evolution of inflammation markers among a subgroup of biological agent naive patients with moderate-to-severe plaque psoriasis at the moment of biologic therapy initiation and after 6 months of treatment. ANA, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophils-to-leukocytes rates (NLR) were analysed in the second Department of Dermatology, at Colentina Clinical Hospital in Bucharest. ELISA method was used for ANA levels, serum CRP levels were measured quantitatively with the immunoturbidimetric method, ESR was measured with the Westergreen method, and NLR was calculated using Fluorescence Flow Cytometry values of neutrophils and leukocytes. Our preliminary results indicate that, although inflammatory markers are present in a severity-dependent manner, there is no substantial evidence of autoimmune involvement. Further detailed findings will be presented in our paper, as the inclusion period for the study remains ongoing until the end of the month.