Phenotypic antibiotic resistance of <i>Mycoplasma genitalium</i> and its variation between different macrolide resistance-associated mutations
This study revealed that M. genitalium isolates vary in azithromycin-induced growth inhibition across MRAMs, potentially explaining differences in clinical treatment efficacy. Phenotypic susceptibility testing for other antibiotics demonstrated relatively low MICs. Future studies should incorporate clinical treatment efficacy and symptom severity to optimize treatment for M. genitalium.
Authors
- Nikki Adriaens (ORCID: https://orcid.org/0000-0003-0358-2555)
- Sylvia Maria Bruisten (ORCID: https://orcid.org/0000-0003-4897-4261)
- Brenda M. Westerhuis (ORCID: https://orcid.org/0000-0002-3207-0447)
- Alje P. van Dam
- Clarissa E. Vergunst
- Frederique Bouwman (ORCID: https://orcid.org/0000-0001-6068-4676)
- Tessa A. Doelman
Institutions
- Noordwest Ziekenhuisgroep (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1093/jac/dkae430
- Citations
- 1
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Statens Serum Institut